(1 Clinical Laboratory, The First Affiliated Hospital Of Chongqing Medical University; Chongqing 400016,China) 【Abstract】Object:To evaluate the capability of different POCT glucose meter and understand the difference between the venous blood glucose results with POCT glucose meters and the blood glucose results tested by biochemical analyzer. Methods：The accuracy,reportable range,comparison with biochemical analyzer were detected by the different instrument with heparin whole blood. All statistical analyses were performed with SPSS version 11.0 statistical software.Results：The within-CV% of Sure-Step, Accu-Chek Active, ONE Touch POCT glucose meters were 2.36-2.54%、1.06-1.25%、4.20-4.66% respectively, regression equation with biochemical analyzer (AU5400) were Y = 1.0299X +0.1789, Y = 0.8611X +0.5276, Y = 0.9267X-0.0697 respectively.In the medical decision level,the differences from comparison with the target detection systems was ＜20%. Conclusion:There is significant differences between different POCT glucose meters and blood glucose and biochemical analysis of the results detected. POCT glucose testing method can be used as the selection, but not a substitute for blood glucose measured biochemical analyzer.