Diagnostic and therapeutic effect Value of Serum Tumor Markers for Lung Cancer Ma Zhi jin Department of Clinical inspection，Ben xi Central Hospital，117000, Liao ning 【Abstract】Objective To evaluate CEA，CA125，CA50，?2-MG，NSE and CYFRA21-1 used alone or in combination for the diagnosis of lung cancer ．Methods The serum levels of six tumor markers：CEA，CA125， CA50，?2-MG，NSE and CYFRA21-1 were detected by Elecsys 2010 electrochemiluminescence analysator in 85 patients with lung cancer，62 patients with benign lung disease(BLD) and 28 healthy adults．Results The serum levels of the six tumor markers were significantly higher in lung cancer patients than in benign intestinal patients and healthy adults( p<0.01 )．In patients after lung cancer operation，the serum levels of CEA，CYFRA21-1，CA125 and CA50 were significantly lower( P<0.01 )．Although with higher levels in lung tumors，no statistical difference in serum levels of CEA，CA50 and ?2-MG was found in the four different tumor types．The expression of CYFRA21-1 in squamous cancer was higher than that in the three other type tumors(p<0.05)．NSE expressed highest in small cell lung cancer( P <0.01)，while CA125 expressed highest in adenocarcinoma( P<0.01)．Conclusion The six tumor markers can be good indices for early diagnosis of lung cancer，and combined detection of CYFRA21-1+CA125+NSE will be better for the diagnosis and treatment for lung Cancer．