Objectiv To study the changes of serum myocardial enzymes in the children with hand, foot and mouth disease(HFMD) and explore its clinical significance1．Methods Fasting serum myocardial enzymes, excluding aspartate aminotransferase(AST) , lactate dehydrogenase (LDH) , creatine kinase (CK) and creatine kinase isoenzyme (CK - MB) were examined in 187 cases with HFMD diagnosed the next day and the end of course of disease. Results The children with HFMD had higher myocardial enzymes than the control group(P＜0．01),and before Treatment group had higher myocardial enzymes than convalescence following treatment group(P＜0．01),but had not myocarditis manifestation. Conclusion myocardium was easy to be damaged with HFMD, After the treatment with good prognosis.